When you say you have no mods, does this mean you never ever tried mods on this computer system yet?
Reason I ask is because if you used mods in the past and later removed them, they might still be spooking up with left overs until you do a proper full clean reinstall of the game.
I assume these honor mode runs were started with a clean install of the game with no modding behind them, with that being said I suspect you might want to be more persistent with the Larian Support staff, something might be getting corrupted when it always happens at the same specific spot of the game.
What did the support suggest?
I have not had any mods except that which allows Minthara to be recruited if you failed some conditions in act 1 but that was in my normal run. Before starting my most recent HM run I reinstalled the game 3 times (because 3 times I had this issue in Last Light inn) Support suggestions were use a savefile they provided, disabling/enabling the steam sync, trying vulkan, renaming bin and verifying integrity, renaming appdata folder.
Have you installed the toolkit?
I didn't know it existed before you said honestly, I will check it out!
