I ran into almost the same thing after patching BG3, my settings just wouldn't stick even after editing the files manually. What finally solved it for me was launching the game as administrator, then making changes and exiting right after. That forced the config to save properly the next time. It’s definitely buggy, especially after some new updates. Dealing with stuff like this kind of reminds me how you need to double-check your preferences when using apps, like learning
how to record a video on zoom so you don’t miss anything important because of a setting that didn’t save right the first time.
