Hi, I tried one last time from my end of act 2 save and changed 2 things :
• I activated the cross platform save through Larian Cloud (which was off for me before)
• I saved only on a new manual save with no number or special characters in the save name
I don't know which of these two fixed it but I've played around 15hrs since then and for now, I can still reload from that save file whenever I want during act 3 so I can start quick saving regularly and enjoy the game again.
Hope this works for you as well