Can confirm on ps5 as well. Started a new play through with all the mods i had installed about two weeks ago, game was running completely fine & smooth at first until reaching the emerald grove.
The game became more unstable the more i played it until i got to act 2, & now my save crashes as soon as it hits 100% upon loading.
went back to an unmodded act 3 save that was concluded, and was still experiencing lag & stutters, not as bad as modded but 100% wasn’t there before the update (2/16).