If you switched to PC to play with more mods... Why wouldn't you play with mods?
Seems silly to deny yourself the exact reason you made the switch.
I think he was wondering about the diffferent controls and if starting with mods would make it more confusing, so if it would be better to do the FIRST run (you missed that word, I guess) without mods.
Answer is, use mods that you like on the first PC run. You won't miss anything out from doing a vanilla run first.
