I think he was wondering about the diffferent controls and if starting with mods would make it more confusing, so if it would be better to do the FIRST run (you missed that word, I guess) without mods.
I didn't miss that word. It just didn't seem too relevant given the context of being a veteran of the game.
If it was his first EVER playthrough of the game, then sure. I'd understand how modding might not be the most desirable thing to do as well, 1) You won't know what you'd like to mod and 2) It can drastically change your experience with the game.
But with it just being a switch from console to PC I don't get it. Like, yes, there's some difference in controls. But not massively (It's still a turn based CRPG regardless of what platform you're on). Also, given that the focus is on QoL and appearance mods, it's not as if actual gameplay is going to be affected to the point where control schemes are a factor. Unless their focus is on hotbar mods, which I doubt they would be if they haven't got experience with the PC's hotbar.
So it comes across as strange. Like, they know the game well. They are used to modded runs. They swap platform specifically to get more mods. Then are worried about using mods?
The only tangible concern I could fathom was the quip about achievements and challenging themself, suggesting they might care to go after achievements without their QoL mods. Though if they're truly QoL and not power mods then I don't see the reason to be concerned over that.
I mean, at the very least, you can stick to mods you're used to using and/or lower impact stuff. You don't necessarily have to dive into the larger array of PC mods if you have any qualms about playing on PC.