I am playing the steam version using Vulcan on Ultra Wide (3840x1080) and all the interactive object's UI zone are off-center. I have to move the mouse in a circular pattern slowly outwards from the item/object till the it highlighted. A lot of times it is about half an inch to an inch away on screen.
This isn't a big problem for chest and containers as Alt-highlight allows me to just click on the item nameplate. But for things like books, buttons, levers, etc. it is really a pain.