I don't know if I am the only one to experience this, but using a 120GB HDD, I am having the occasional problem with Divinity II DKS (always connected to live so will be up-to-date patch wise)
Once in a while I select Save, choose a save slot and during the preparation before starting to write to memory the console / game freezes.
If this happens I have to power off / On the 360, naturally I also lose my progress.
Am I alone in this? I know it may be a HDD error, but I doubt it, the game freezes during pre save preparation, not while saving.