I think you might have "Alfie" quest bug, if you rescue him it crashes next time you try to travel to Luculla Forest.
There's a work around, if you let him die it seems to be okay (no crashes)
Unfortunately not, or at least not for me. The first time around we rescued Alfie and his owners, saved soon after, loaded the save on the next day and it was corrupted. We then loaded an older save, repeated the quest, failed to save Alfie and his (male) owner, saved anyway soon after and the next day the file was corrupted, too.
But if the quest is really the reason for this, do you think it can be patched in a way that makes our files work again?