Some bits of the Braccus gear is cursed, although you can un-curse whoever's wearing it with the bless spell. I'm not sure about anything else, though I have seen equipment with various penalties on stuff like sight, movement, lucky charm etc.
I guess we'll have to wait to see what happens with crafting: very little is actually implemented so far...
When I get that far I'll have to check out Braccus' gear. Thanks for the heads up!
I was thinking more items that have a hard penalty like having -50 reputation to people you talk to. The small penalties don't really do much for me.
Hopefully Larian lets us craft some cursed stuff.