One of the big pluses for DOS1 was that there were often many ways to solve puzzles and progress quests without breaking the game.
I'm hoping DOS2 is the same. For example, in driftwood there is a mystery / investigation ongoing about some dissappearing Magisters. I decided to write my own ending for that quest (they dissappeared because my party wiped them out, including Reimond before he could skip town).
I'm hopeful that there aren't any situations where the demise of a magister (or bystander collateral damage) will block progression.