Ok, so I have two bugs I've hit so far to report that are pretty specific
The big one, I got up to the point where I took out the Zhent lads in the cavern (after beating the Gnolls), unlocking the chest, stealing the flask, passing the Arcana check to identify the flask, etc. Now I've tried about 5 times to unseal the flask but each time it gets to the dialogue line about a creature appearing, but no animation happens and no creature appears, leaving my character stuck in the dialogue and unable to act or get out of it other than reloading. This happened the same each time I attempted it. The background animations during the cutaway to the flask happen but the flask is frozen in space, I can switch out to other characters, push the stuck character around, etc, but nothing breaks him out of his dialogue window. I'd had this happen once before, at the camp with the skeleton near the Grove where there was the bag full of spiders wedged in a crack in the rocks. Same thing happened where the game stopped at a dialogue line and wouldn't allow me past it, but that only happened one time, and clicking the attack option broke the lock even though there were no creatures there to attack. I tried that same fix with the iron flask bug and it didn't do anything.
Second thing I've had happen turned into a bit of a running joke with my friend I was in co-op with, because it's happened twice. The issue involves killing creatures with effects that push them (ie Repelling Blast or Pushing Attack or Thunderwave) and the body landing in bushes. I had this happen with one of the goblins in the attack on the gate of the grove, and with the bugbear assassin attacking the tiefling girl up near the telescope. In both cases, once the body is found in the bushes, there is no place on the body where you can click it to loot it. I pixel-hunted for a while in both cases trying to get an angle where I could loot, but no luck. This turned into a joke because it was like how in the sniper levels of Hitman 2016 and its sequel, if you use your high-powered sniper rifle to shoot someone in such a way that their body is thrown into a bush, everyone acts like the body doesn't exist.