when i retrieve the chest from the merc caravan that was ambushed by gnolls, and give it back to their leader in the cave camp, game treats it like i both have and have not opened it. i have the option to ask about the flask inside (which i shouldnt know about), but i also can give the box back unopened, and she accepts it. after that i still have the option to feed the bottle to gale in my camp (although i never opened the box in this savegame)