Opening the caravan strongbox, the one related to valuable shipment quest, cause a ruined savegame problem.

I killed the gnolls and got the crate to deliver at the hideout. At the campsite i opened it and you know what happens unsealig what's inside, poor Scratch. I reloaded the savegame before unplugging the flask and kept playing. After a couple hours i met the Githyanki and had to reload discovering that all and every saves after opening the chest caused a crash when loading.

Doing a few experiments i noticed that's opening the chest not unplugging the flask that makes the savegames corrupted, a very annoying problem because you realize it occurred a lot of time later.
Searching around i found on Reddit that the problem seem to happen only if you open the chest at the camp