I'm in the habit of pressing F5 before every major battle and every conversation where I know there are important dialog choices. I will also routinely hit F5 after such things too. Then I go about my business. Something happens where I have to reload, and instead of loading the one I JUST did 10 seconds prior to the action, I get one from an hour or more ago. In fact, the one or more quick saves I've done since the one that loaded don't even show in the list. I've been waiting for the "Save Successful" banner to appear and disappear before attempting any game action, but it doesn't seem to make a difference. Sometimes it just fails.