For me, saving didn't work at all with the latest patch.
Trying to save manually, quicksave or autosave created an error message (save failed - something) but I could keep playing (useless, since I couldn't save the progress, but the game kept working otherwise) and trying to delete an old save crashed/froze the game.
Re-rolling to the former patch solved this.
Oh, and playing in full-screen is a major PITA if something like this happens, since the game insists on staying in the foreground. Even Task Manager can't be accessed (had to hard shut-down my pc because I simply couldn't get the game to shut down any other way.
This "I will stay in the foreground no matter what" also lead to me not realizing the error messages with re. to failed saves for quite some time, since the pop-up message was covered by the game-window.