In theory it is possible, whether the engine or the editor allows this change to be made externally is anyone's guess I would guess you would need to specifically code in the ability to manage the time state of the game in mods.
Meaning, that the engine is always turn based, just outside of combat a turn is roughly 8 seconds (from an old interview so the actual time may have changed) in real time. The one exception to this seem to be summon skills who afaik do not expire in turn based mode (at least they have not for me), but have a 30 expire on them in real time mode (also controlling summons in real time mode was disabled for some reason).
So because the real time exploration is actually technically simulated turns it should be possible to use similar simulation for combat, whether it would be playable as is I have no clue.