I use ESDF instead of the WASD which most games utilize for movement as well as a few other changes. I change the keybindings for "Move Forward" to "E" and "Toggle Map" to "X". The other changes I make do not have a problem and it seems to be just with these two keys.
Because E and X are tied to other functions you get the popup asking if you would like to unbind them to those other functions during the process. This works for the duration of the current gaming session however if I exit and log back in the other functions those keys were bound to reset to default.