The issue with this error is being investigated.
If you have not already checked your firewall settings and disabled your anti-virus, this can also be caused by internet access being blocked for the game.
To check in Windows Firewall:
- click Start, then Control Panel
- in Category view, click System and Security, then under Windows Firewall,
click 'Allow a program through Window Firewall'
- scroll down the list and make sure both entries for 'Divinity Original
Sin 2' (EoCApp.exe and SupportTool.exe) are checked off to have Public and
Private access.
To bypass the Support Tool, you can start the game directly from the '..\SteamApps\common\Divinity Original Sin 2\bin\EoCApp.exe' program file (or similarly for the GOG install path). Right click drag and drop the executable to the desktop to get a menu option to create a shortcut. As long as Steam is running, the game should be able to connect to make Steamworks functions available (multiplayer lobby, etc). Alternately, you should be able to rename the SupportTool.exe executable in the install folder, make a copy of EoCApp.exe and rename it SupportTool.exe to continue starting the game through Steam.