One of the many nice things about D:OS2 is that it has several note worthy origin characters. You can't fully explore all of their stories in a single play through so the adds a bit of replayability to the game. As a further note, conversations of origin characters can be a bit different if you are playing them as your main character rather than having them as a companion. Also, origin characters will react to decisions made by other origin characters. The Red Prince and Sebille make for an interesting pair to run together. In my opinion, Lohse has the most interesting story. Playing as Fane has an added benefit that game itself will teach you how improve combat against undead. However, playing as your own unique undead character will do that as well. I enjoy playing an undead Elf as a Necromancer. What says Necromancer more than a character that eats body parts?
As for a recommendation on a first playthroung, perhaps the best thing to do is plan a group around the TAGs (Soldier, Outlaw, Noble, etc). Try to have a party that maximizes the number of these you have in the party. For a first playthrough, the two I would recommend would be Fane and the Red Prince. Get Pet Pal on the Red Prince. There are a couple reasons for this and one of them is humorous, but you requested no spoilers. Another recommendation for a first play through would be having an Elf in the party. This can be your own original character or bringing Sebille along. Taking the Red Prince, Fane and Sebille with give you the TAGs : Scholar, Mystic, Noble, Outlaw. That just leaves Barbarian, Soldier and Jester. On a first play through, Soldier is a good option. As such, I would recommend going with Ifan or your own character with Soldier. Again, feel free to plan to try some of these out on a future play through.
Explore and enjoy the game as so many of have.