Are you shutting down all non-essential programs before starting the game, especially anti-virus and any backup programs that may be monitoring the My Documents folder?
Try browsing to the '..\Documents\Larian Studios\Divinity Original Sin 2 Definitive Edition\LevelCache' folder and delete the contents. A corrupt file there can cause problems when saving or loading, and could be region specific.
Try exiting out of the Steam client, if applicable, and starting the game directly from the '..\SteamApps\common\Divinity Original Sin 2\DefEd\bin\EoCApp.exe' program file, by right clicking and running as administrator.
Try lowering the graphics settings and resolution, and switch to Windowed or Fake Fullscreen display mode, to see if that will make a difference.
Later regions of the game are larger, so take longer to load and use more memory, which could be a factor with the crashing.
As soon as I delete the latest savegame entry (either quicksave or normal) loading a savegame does work again!
So whenever this happens, just the latest save is corrupt (or otherwise causing the problem with loading any save)?
Does copying the 2 or 3 most recent saves to a new profile, rather than the full set of saves, allow you to reproduce the problem and fix, as well?
If so, please email supportdos2@larian.com with those saves (or a Dropbox or Google drive link, etc). If you are using any non-Larian mods, also include a list of those enabled and/or the modsettings.lsx file from your profile folder.
In Windows Explorer you can zip a file or folder by right clicking on it/them and selecting 'Send To | Compressed (zipped) Folder'.