I've completed the quest, spoke to Rath and got the wolf rune.
I place the rune in the open slot, then clicked it and it glowed; then proceeded to click the remaining runes and nothing happened.
So, I googled it, saw one vid where the player clicked the runes in a counter clockwise direction and the cache opened, tried it and nothing.
Then tried a different utube and this other player clicked the runes in a clockwise direction and it opened, I tried in my game and nothing happens.
It's one of two things in my opinion. The quest was changed or it's bugged.