It is the same guy. I have no idea, though, whether there’s any existing lore that would connect Blood Hunters to Faerun/Toril. As I understand it, this is a class developed for Matt Mercer’s own setting of Exandria?
Though I’m all for giving players the maximum flexibility to create the characters they want, especially in single player games, personally I prefer to play characters I can connect to in-world canon. (Not that I’m expecting the Blood Hunter class to be implemented by Larian, given it’s not yet official let alone PHB, but I’d still be interested to hear whether it’s a class anyone has started incorporating into Faerun-set games or media.)
For me Blood Hunters fit best to Zariel-Tieflings, besides Vengeance Palas.
Blood hunters are clever warriors driven by an unending determination to destroy evils old and new. Armed with rites of secretive blood magic and a willingness to sacrifice their own vitality and humanity for their cause, they protect the realms from the shadows — even as they remain ever vigilant against being drawn to the darkness that consumes the monsters they hunt.
The BH description reminds me a lot of Zariels path:
"My legions are the only thing standing between your precious Seven Heavens and the bottomless hunger of the Abyss. I did not fall into the clutches of evil. I rose to shoulder a cosmic burden." — Zariel