I see only 2 main problems:

1.) Not being able to set up keys to scroll east/west/north/south.
2.) It is VERY hard to move anything. Sometimes it works right away, sometimes it takes 15 attempts. Examples are barrels/chairs/garbage..picking up decapitated heads..hands. I cannot figure out why this happens, and I've played around with it for a long time trying to find a common occurrence when this happens. I'd say it's a pain to move/grab normal items at least 75% of the time. I've tried it in every resolution of the game.