<img src="/ubbthreads/images/graemlins/eek.gif" alt="" /> That would be nothing for me. <img src="/ubbthreads/images/graemlins/winkwink.gif" alt="" />
If you put 'slash' on key 1 and 'roundswing' on key 2 and 'overheadslash' on key 3, etc. And give me a pause button... then it would be ok. At least without the 'locking on'. <img src="/ubbthreads/images/graemlins/winkwink.gif" alt="" /> But if I have to remember in what order I have to press WASD and Mouse1/2 then I'll uninstall the game rather quick.
It depends on how the rest of the control scheme would work. If the mouse controlled the camera, simply by keeping your 'mouse' upon said creature for more than 1 second, and if they are within x meters(or units) of your character, they become locked until you move the mouse outside of a bounding box of the creature.
The system I described is pretty much "slash on key 1", and complex moves a "logical combination of WASD keys in combination of slash on key 1". Such as if you wanted to lunge forward, press W in rapid succession twice followed by the "key 1". I think it'd be a rather simple yet dynamic system that would allow enough tactics and skills/stats to still come into play - thus removing a lot of the "twitch" factor while still feeling well-paced.
But maybe it's just me <img src="/ubbthreads/images/graemlins/winkwink.gif" alt="" />