*The npc's talk as though they are constantly avoiding being hit by kamikaze mosquitoes

That really stuck out in some of the gameplay videos. I can see wanting some flourish, so NPCs don't look like statues, but used constantly it is a little much. I don't think it would seriously detract from the overall game for me, but I'd certainly tone it down if that was an option.

*The quest system is lacking on destination points.

Do you mean many quests lack any kind of logical hints on where to go or who/what to look out for, so you basically explore everywhere and sometimes just come upon a quest solution?
Or is there some direction given, but not detailed enough?