Interesting update: I just discovered that if I press the escape key *really* fast in the moment I'm seeing the opening Larian logo before crash, it skips me to the menu and lets me play.

From there, I changed resolution settings, etc. but run into the exact same crash when I restart. I can technically get into the game now after a few tries of hitting escape in time, but the problem remains. Maybe this new info will help you pinpoint what may be causing the instability?