Well sure, that's why I suggested that a hybrid system might have been a good compromise. It would have assured a more "even" distribution of loot, while maintaining some degree of randomness to keep the player guessing.

Things like Unique Boss weapons or quest-dropped items (such as the panties) are nice, but early-to-mid game those are few and far between. If a player is ready to build their team around those kinds of items, to ensure that they'll be able to use one of the few non-random drops, that's fine. But that kind of thing requires foreknowledge of what the game is going to throw at you.