Are people still crashing during the saves? Thats the worst
In my playthrough it crashed during quicksaving maybe five times (in 100 hours). No big deal. But I've heard the problem can be much worse if you have a 32bit OS and only 4GB RAM.
I have 4GB ram but has 64 bit. So far, did not encounter any crash in my 8 hour (alpha) and 2 hour playthrough (release).