I also have this saving issue, which really is annoying. It happens every third or fourth save, no matter where and regardless of autosave, quick save or normal save. The turning icon begins to stutter, sound does as well and gets stuck in a loop and the game just shuts down leaving me at the desktop. There is no error message, game is just gone. I lowered graphics, deactivated autosave (to not get surprised by the next crash) and reduced the quick save slots to 2, didn't help.
To a "save early, save often" game this bug hurts quite a lot.