You could try browsing to the '..\Documents\Larian Studios' folder and renaming the 'Divinity Original Sin' subfolder.
This folder contains the saved games, configuration files and a level cache folder. Deleting or renaming it will get the game to recreate it on startup; playing the game from a different Windows user account would effectively do the same thing.
After that, start D:OS, create a new profile, exit and copy your latest save from the renamed folder to the newly created profile's savegames folder.
If that doesn't help, you can delete the new D:OS folder and rename your original back again.