"Hovering over the target will also show your chance of a successful hit on that enemy. Your chance depends on the primary statistic related to your specific type of attack and weapon,your offence rating , as well as the enemy's defence rating. Enemies with lower defence ratings tend to be easy to attack, while those with higher defence ratings can be very difficult to hit."
Your chance to hit depends not only on your offence rating but also on the enemy's defence rating. So, if you see a very low chance to hit, then the enemy has a very high defence rating - one of the possible reasons is that you are fighting enemies who are above your level. When I picked up fights with my level 11 characters against level 14 spiders, then the chance to hit of my warrior was even worse than 49% - it was actually just 29%. Btw, my warrior had strength of 13 at this time.