It seems that you can no longer pan the screen by mouse movement, you have to use WASD or the arrow keys.
There's a setting in the game options for panning the screen by moving your mouse to the edge.
However, the space bar while looting functionality has been broken. Space is grab all. When items are in the container it grabs all and then closes the container (as it should, and as it did). When you his space and there are no items in the container, nothing happens. A bit annoying as D:OS definitely had space closing containers.