All of the quest npcs are hostile towards 1 of my main characters. Even npcs I run into for the very first time. They attack him on sight. Fleeing from the fight does not fix it. My other character IS able to talk to them and start/complete quests though. Not all npcs are hostile on sight though. I am able to talk to vendor npcs and trade and such. This isn't game breaking for me(yet), but it is a huge annoyance. I can't have the character around any quest npc until the quest is complete and/or the npc leaves. If theres a battle involved with the npc, I have to have my character flee battle before the end. In some instances I can't go in certain areas in towns since it will start a battle and everyone around will join the fight.