Low numbers are visually cleaner, for example:
361 hp 46 damage
Compare to:
3645943 hp and 464356 damage

And high item obsoletion rate make getting good new items feel much less rewarding, a better system to many players here would be the best items can be found throughout the game, but a player won't have enough of them to fill every item slots until the very late game.

I don't see how inflation is needed to make resource mangement interesting. It is not necessary for a survival game, Rogue-like or old-school dungeon crawling RPG, why it is needed for D:OS2?