I edited a Talent one of my two main characters and it worked great. Not a single glitch.
( Windows 10 Pro ; game on Steam of March 2020 )
Note it is the only thing I edited.
One minor error in the software : the UI offered me a Talent (Elemental Ranger) that requires Expert Marksmen 5 though the character has 4 currently.
Short story : I had bought the wrong Talent and the respec system in-game takes a long time to unlock and cost a lot (buying back all the Skill Books).