The spiders are best eliminated slowly. If you sneak in to the bottom of the cave you can eliminate them one by one as well as sneaking to kill the eggs. So by the time you get to the Queen she's all that's left. Just lure her onto a web and burn the web so she drops into the pit below. If that doesn't work place your guys strategically so she can only ever hit one and keep shooting her.
Beaten her once so far. Didn't realise I could burn the webs. Something new to try out
