I just ran into a pseudo-consistent soft-lock glitch involving several of Shadowheart's dialogue Rolling options, where the game would initiate the Dice Roll screen but would not allow me to start the die roll. You cannot leave this screen without rolling the die and you cannot load a save during. You must restart your game. I'm unsure what is causing the issue. I've had it trigger on her dialogue that was prompted by the Owlbear Gilded Chest and by the Damaged Helmet in the Goblin Ambush village.