I really want to play as Lae'zel, Shadowheart and Astarion. The horny wizard and the horny warlock not so much.
I am worried playing as an origin character will have the effect of missing lots of their lines in cinematics. And I like Shadowheart's voice so much I would rather have her as a companion for this very reason.
Personally I think I'm going to save origin character playthroughs for subsequent playthroughs because of this. I'll treat it as if I'm experiencing the same story [the companion's story] but directly through their eyes.