I am playing DDO a lot with a real time combat system. In my opinion Larian made a good compromise between both worlds.
If you use real time combat the player is much more dependent on the AI of the PCs because you can‘t react fast enough for 4 PCs in comparison to playing only a lone wolf.
AndI don‘t like pausing games every few seconds for combat mechanics. In fact I was expecting a turn based system knowing it from pen&paper.