Reaction Popup: No, Reaction Popup: NO, Reaction Popup: HELL NO.

Computers don't have intelligence, they will hard spam you with popups. Reaction is fine in Pen and Paper, as I can say do reaction and the human DM can handle it, but the other way around is messed up, you do not want the DM to ask you every time a reaction is possible.

You do not want to create a situation where you give players game stopping popups when one of the answers is DO NOTHING. This one of the worst design mistakes, because humans just doesn't have the capacity to endlessly respond to the same and enjoy it.