Bottom line.

Party of 4 multiplayer = 0 party slots = Absolutely no ability to enjoy the full game because you can't do a single origin character quest because you can't include a single origin character in your party.

Party of 6 with 4 player max = 2 party slots so party of 4 multiplayer CAN enjoy the full game because you can do a origin character quest because you can include 2 origin characters in your party.

+ Less switching out party members
+ More character banter and interaction
+ Party can carry more so less hassle with item management (less running back to the merchant to sell)

And so much more