Speaking of minor compromises to decrease frequency of prompts, talking with a friend made me think that I probably wouldn't mind too much if some reactions were triggered only under the condition of their impact being meaningful.
Example: Shield. Instead of being prompted to use it as soon as targeted by an attack, being prompted only when that +5 to AC would save you from the attack roll that enemy just made.
Not a MASSIVE difference all things considered, but hey.
Party control in Baldur's Gate 3 is a complete mess that begs to be addressed. SAY NO TO THE TOILET CHAIN