Idk if anyone else has said something like this but honestly the best way to do it imo is keep the layout as it is and tweak like this:
Reaction toggled on = automatic yes no matter what. Toggled off = ask the player whenever the opportunity rises to use it - left click for yes right click for no. Removed from hotbar (or a third toggle maybe, with a red X across the icon) = automatic no, no matter what.
I don't want to be bombarded with yes/no's every turn for reactions I barely use. Being able to fully customise the rate of automatic uses (and not-uses) per reaction would be way more streamlined, and then you can have the yes/no for the most situational of them all.