It's interesting to note that other similar games such as Pillars of Eternity and Pathfinder have a party limit of 5.
PoE is 5, Owlcat's games are 6.
I'm currently playing WH40K Rogue Trader on Daring difficulty (basically Core) and it is difficult enough with a party of 6. There's a Hard and an Unfair difficulty after Daring and all difficulties are fully tweakable.
The game is designed for a party of 6 with most fights involving at least twice your number of enemies. Even the boss fight at the end of the tutorial was grim. The boss was a 140 HP Chaos monster with two attacks per turn who when he got low on health devoured a minion to bump his health back up. He also had toxic gunge splash type AOE thing. At this point you only have 4 party members and you HP is 25-30-ish. You have a few ship's crew to help you but they are not great.