I am running three screens at 5760x1080 using nVidia Surround. There is a problem with using the cursor over objects. Anything that is in the center of the screen, I can move the cursor over the image and it highlights as normal. However, if an object is off to the left or right, I have to move the cursor further to the left or right off of the object in order for the object to highlight.
I have had to reduce the game graphics to 1920x1080 in order to avoid this problem.