The hotfix was released, and it was for the Classic version of the game.
blasphenomen;
Does it matter if you load a save on the ship or after getting to Fort Joy?
During the same play session, is there any problem when reloading the current or previous saves?
In OSX, what file system are you using? I think case-insensitive APFS is default since High Sierra (HFS+ case-insensitive before that). You can check in Disk Utility (/Applications/Utilities).
If you are using a case sensitive file system, try creating a new OSX administrator user account with the Documents folder on case insensitive partition, if available, switch to that account and try starting the game from there to test.
If you are using a case insensitive file system, you could still try a new account with a Documents folder on a different drive, if available.
Are you shutting down all non-essential programs before starting the game, especially anti-virus and any backup programs that may be monitoring the Documents folder?
If you create a new profile, start a new game, explore a bit and save, does the map reset after restarting the game?
Try doing a clean boot and then test the game. Start/restart your Mac and hold the Shift key down as soon as the progress bar comes up in the startup window, releasing it after the desktop appears. Alternately, from the login window, hold the Shift key when you click the Log In button, and release it when you see the Dock.
Try browsing to the ~/Documents/Larian Studios/Divinity Original Sin 2 Definitive Edition/LevelCache folder and delete the contents. A corrupt file there can cause problems, generally when saving or loading.
If that doesn't help, please email supportdos2@larian.com with your latest save (or a Dropbox or Google drive link, etc), and maybe one from the ship section, if available. If you are using any non-Larian mods, also include a list of those enabled and/or the modsettings.lsx file from your profile folder.
Each save is a folder in the '/Documents/Larian Studios/Divinity Original Sin 2 Definitive Edition/PlayerProfiles/<ProfileName>/Savegames/Story' folder.
In Finder you can zip a file or folder by right clicking on it/them and selecting compress.
Also include the rest of your system specs (you can use the 'System Report' button from the 'About This Mac' Apple menu item, or the 'System Information' app in the utilities folder), including the OS version number.